Scientist I - ML/AI Foundational Models

Scientist I – ML/AI foundational models for synthetic enhancer design

The Allen Institute accelerates science for a healthier world through large-scale research designed to answer some of the most complex questions in biology. Our multi-disciplinary teams generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work. We share our work openly so others can build on it, move faster, and ask bigger questions. We drive discovery forward and create new possibilities for improving human health.

Brain Health is a new global collaborative research initiative designed to accelerate understanding of human brain diseases through large-scale human tissue analysis, open science, AI-enabled disease modeling, and translational platform technologies. Building on foundational advances in human brain cell atlases, quantitative neuropathology, single-cell and spatial biology, multimodal molecular profiling, and AI-enabled analysis, Brain Health is developing a scalable framework for understanding disease progression directly in the human brain and identifying new opportunities for therapeutic development.

We seek a Scientist I to build the computational backbone of a lab-in-the-loop platform that designs and validates synthetic enhancers for precision cell-type targeting in the brain. In this cycle, model-designed sequences are tested experimentally, and the results retrain the next round of models. You will contribute to an open-source codebase…