Senior Data Scientist

Job Description

Senior Scientist, Predictive Immune Biomarkers (R3)

The Precision Genetics group within the Data, AI and Genome Sciences Department is seeking a Senior Scientist to join our Computational Precision Immunology team in Cambridge, MA. We are looking for a skilled data scientist with extensive experience to develop predictive biomarkers in immunology based on multi-modal and multi-scale data analyses.

Key Responsibilities:

• Foundation Models: Build, fine-tune, troubleshoot, and benchmark foundation models for predictive immune biomarker discovery. • Multi-omics Analysis: Perform quality control (QC) and analysis of different molecular data types including bulk and single-cell RNA-seq (e.g., Limma, Seurat, scanpy), spatial transcriptomics (e.g., CosMx, 10x Visium), and proteomics (e.g., OLINK, mass spectrometry-based approaches). • Multi-omics Integration: Integrate multi-omics datasets, including gene/protein expression, spatial transcriptomics, and genotype data. • Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.

Required Qualifications:

• Ph.D. in Computer Science, Engineering, Data Science, AI/ML, Bioinformatics, Computational Biology, Genetics & Genomics, Mathematics, Statistics, Physics, Pharmaceutical Science, or related STEM field. • A proven track record in multi-omics analysis. • Hands-on experience with building, fine-tuning, benchmarking foundation models, preferably for patient stratification…